使用PRO-CTCAE评估与免疫相关的不良事件,在II期研究中对伊皮利穆马布治疗激素敏感前列腺癌进行II期研究
Daniel Vargas P de Almeida1,2, Justine M Anderson1,3, Daniel C Danila1,4
1Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Journal of immunotherapy and precision oncology
|December 25, 2023
概括
患者报告的结果版本的常用术语标准不良事件 (PRO-CTCAE) 有效地捕捉了前列腺癌患者的免疫相关不良事件 (irAEs),在临床医生评估的同时提供了宝贵的患者视角.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 患者报告的结果
背景情况:
- 众所周知,常见术语对不良事件的标准 (PRO-CTCAE) 的患者报告结果版本可以改善化疗期间的结果.
- 关于PRO-CTCAE在监测免疫相关不良事件 (irAEs) 的有用性的数据是有限的.
- 与免疫相关的不良事件 (irAEs) 是癌症免疫治疗中的一个重大问题.
研究的目的:
- 评估PRO-CTCAE用于监测受激素敏感前列腺癌患者接受ipilimumab的irAEs的使用.
- 使用CTCAE v4.0.0.对比患者报告的irrAEs与临床医生评估的毒性使用CTCAE v4.0.0.
主要方法:
- 从NCI的PRO-CTCAE中将与irAE相关的项目纳入临床试验.
- 收集了184对PRO-CTCAE调查和临床医生评估的CTCAE v4.0数据.
- 专注于包括腹痛,腹,疲劳,厌食,恶心,吐,皮疹和等症状.
主要成果:
- 疲劳,腹,皮疹和是患者和临床医生报告的最常见症状.
- PRO-CTCAE和CTCAE之间的一致性在皮疹 (κ = 0.64) 中最高,在 (κ = 0.10) 中最低.
- 比临床医生评估的CTCAE,PRO-CTCAE更常见地和更高的等级上发现了irAEs.
结论:
- 针对irAEs的PRO-CTCAE评估捕捉了患者的免疫疗法经验.
- PRO-CTCAE补充了临床医生的毒性评估.
- 需要进一步的研究才能充分确定PRO-CTCAE在识别和管理IRE方面的作用.
更多相关视频
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
1.5K
06:54MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
11.2K
相关概念视频
Tumor Immunotherapy
529
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
529
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
187
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
187
