含有黄金纳米棒的光敏层次薄膜,用于连续释放药物
Baljinder Singh1, Mamta Ramgopal Chejara1, Myoung-Hwan Park1,2,3,4
1Department of Convergence Science, Sahmyook University, Seoul 01795, South Korea.
ACS omega
|December 25, 2023
概括
这项研究开发了稳定的层次膜,用于连续递送药物. 这些膜在需求时释放坎普托西因和多克索鲁比因,显示出治疗皮肤癌等复杂疾病的前景.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 多种药物加载的层层 (LbL) 薄膜提供受控的连续药物释放.
- 协同作用的药物效应可以提高皮肤癌等复杂疾病的治疗效果.
研究的目的:
- 开发稳定的LbL膜,用于顺序和按需释放坎普托他 (CPT) 和多克索鲁比 (DOX).
- 为了研究刺激反应药物释放机制.
- 评估这个平台在癌症治疗中的潜力.
主要方法:
- 使用聚乙胺,CPT装载金纳米棒 (GNRs),聚乙硫酸盐和DOX通过静电相互作用制造LbL薄膜.
- 药物加载,稳定性和释放动力学的表征.
- 评估pH依赖的DOX释放和近红外 (NIR) 触发的CPT从GNR释放.
主要成果:
- LbL电影成功地同时加载了CPT和DOX,具有可调节的药物内容.
- 使用CPT加载的GNR显示稳定性和NIR吸收.
- 实现了pH依赖的DOX释放和NIR触发的CPT释放.
- 这些膜显示了细胞相容性和抗癌作用.
结论:
- 开发的LbL电影为顺序和刺激响应药物递送提供了一个有效的平台.
- 这种方法具有显著的潜力,可以通过协同和按需药物释放来增强癌症治疗.
- 该平台的可调节性质和刺激响应释放机制为各种治疗应用提供了多功能性.
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