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类风湿性关节炎中的高凝血性:一个图书统计分析和回顾性数据挖掘研究

Fanfan Wang^1,2, Jian Liu¹, Yanyan Fang³

¹The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230038, China.

|December 25, 2023

概括

这项研究揭示了类风湿性关节炎 (RA) 过凝性研究的关键趋势. 炎症和凝血标志物是RA疾病活动的重要风险因素.

科学领域:

类风湿病学类风湿病学
血液学血液学血液学
免疫学免疫学免疫学

背景情况:

类风湿性关节炎 (RA) 是一种自身免疫性疾病,导致慢性炎症,关节损伤和功能丧失.
RA 的进展与凝血-纤维蛋白解析系统的异常有关,导致高凝血状态.
对于RA高凝固性研究而言,仅存在有限的文献计量和可视化分析.

研究的目的:

分析知识结构,研究状况和RA高凝度的趋势,使用文献计量.
通过追溯数据挖掘来评估RA疾病活动评估的炎症和凝血标志物.

主要方法:

957篇关于RA高凝血性 (2010-2023) 的英语文章和评论的图书统计分析. 来自Web of Science核心集合.
使用VOSviewer和CiteSpace对国家,机构,期刊,作者和关键词进行知识映射.
对RA患者数据的回顾性分析,将炎症/凝血标志物与中国患者报告的类风湿关节炎活性指数 (CPRI-RA) 相关联.

主要成果:

美国在出版物和h指数方面处于领先地位;卡罗林斯卡研究所是最多产的机构.
主要研究主题包括炎症,激活,疾病活性和风险,最近的重点是标准,验证,凝血,点和贫血.
炎症标志物 (RF,ESR,CRP) 和凝血标志物 (PLT,DD) 在RA患者中升高;FBG,CRP和ESR与CPRI-RA相关,是独立的风险因素.

结论:

在RA中高凝血性,包括其机制和应用,是最近的一个研究重点.
炎症和凝血标志物被确定为RA疾病活动的独立风险因素 (CPRI-RA).

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