尿液代谢物分析以确定长期COVID的病理机制:试点研究
Maja Taenzer1, Judith Löffler-Ragg1, Andrea Schroll1
1Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
International journal of tryptophan research : IJTR
|December 25, 2023
概括
长期COVID (LC) 和肌痛性脑膜炎/慢性疲劳综合征 (ME/CFS) 患者显示氨基酸代谢和神经递质合成发生变化. 尿代谢学在这些持续性疾病中确定了个性化治疗策略的潜在生物标志物.
科学领域:
- 生物化学 生物化学
- 代谢学 代谢学 代谢学
- 神经科学是一个神经科学.
背景情况:
- 在COVID-19感染后持续的症状,称为长期COVID (LC),影响大约10%的个人.
- 腰痛症状包括疲劳,呼吸障碍,胸痛,睡眠障碍,认知功能障碍和心理健康问题.
- 潜在的机制可能包括炎症,氨基酸代谢改变,自主功能障碍和肠道失调.
研究的目的:
- 用尿液代谢组分析调查长期COVID (LC) 患者的代谢特征.
- 确定LC和肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 失调路径的潜在生物标志物.
- 探索改变代谢物和患者症状之间的关联,使个性化医疗成为可能.
主要方法:
- 与健康对照组 (Ctrl, n=8) 相比,对LC (n=25) 和ME/CFS (n=8) 的患者进行了尿液代谢组分析.
- 量化了托芬,氨酸及其下游代谢物的度.
- 研究了代谢物水平与疲劳,焦虑和抑郁等症状之间的关联.
主要成果:
- 与对照组相比,在LC和ME/CFS组中,氨水平显著降低.
- 托和氨酸的下游代谢物 (例如,血清素,多巴胺) 在LC患者中显示出偏差.
- 与症状相关的特定代谢物:疲劳 (低基努伦因,氨酸,Kyn/Trp比),焦虑 (低GABA,高KMO活性).
结论:
- 在LC和ME/CFS患者中,氨基酸代谢和神经递质合成受到干扰.
- 已识别的代谢物及其调节障碍显示为LC和ME/CFS的生物标志物具有前途.
- 这些生物标志物可以为患有持续后病毒综合征的患者提供个性化治疗策略.
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