中年和老年2型糖尿病患者的长期血糖变化和认知功能之间的相关性:一项回顾性研究
JingCheng Ding1, Qian Shi1, Qian Tao1
1Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
PeerJ
|December 25, 2023
概括
长期的血糖变化,包括HbA1c-SD和FPG-SD,对2型糖尿病患者的认知功能产生负面影响. 较高的变异性增加了认知能力下降的风险,而改善的功能和某些药物提供了保护.
科学领域:
- 内分泌学和新陈代谢学
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
背景情况:
- 2型糖尿病 (T2DM) 在中年和老年人群中普遍存在.
- 认知障碍是老年T2DM患者的一个重要问题.
- 长期的血糖变化和认知功能之间的关系需要进一步阐明.
研究的目的:
- 研究中年和老年T2DM患者的长期血糖变化和认知功能之间的相关性.
- 确定影响认知衰退的风险因素和保护因素,在这个人口群体中.
主要方法:
- 对222名T2DM患者的回顾性分析,通过MoCA和MMSE评估认知功能.
- 分类为轻度认知障碍 (MCI) 和非MCI组.
- 使用HbA1c-SD和FPG-SD测量长期的血糖变异性;统计分析包括t-test,Chi-Square,Mann-Whitney U,Kendall的相关性,逻辑回归和ROC分析.
主要成果:
- 在MCI和非MCI组之间观察到年龄,认知得分,血糖变异性 (HbA1c-SD,FPG-SD) 和功能 (eGFR) 的显著差异.
- HbA1c-SD,FPG-SD和吸烟被确定为认知功能障碍的危险因素.
- eGFR,GLP-1RA和SGLT-2i的使用表明对认知功能有保护作用.
结论:
- 长期的血糖变化,特别是HbA1c-SD,显著影响T2DM患者的认知功能.
- 较高的血糖变化与较差的认知结果有关.
- 功能和特定的糖尿病药物 (GLP-1RA,SGLT-2i) 在保持认知健康方面起着保护作用.
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