相关实验视频

Updated: Jul 7, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

在心房动中,circRNA/lncRNA-miRNA-mRNA轴的进展

Jia-le Wen^1,2, Zhong-Bao Ruan¹, Fei Wang¹

¹Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China.

|December 25, 2023

概括

非编码RNAs (ncRNAs) 通过竞争性内源RNA (ceRNA) 机制在心房 (AF) 的发展中至关重要. 针对这些ncRNA通路为AF诊断,预后和治疗提供了潜在的潜力.

科学领域:

心脏病学心脏病学
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

心房动 (AF) 是一种常见的心律障碍,需要更好的生物标志物和治疗方法.
非编码RNAs (ncRNAs) 越来越多地被认为是它们在AF病变发生中的作用.
竞争性内源RNA (ceRNA) 网络是涉及ncRNAs的一个关键机制.

研究的目的:

审查ncRNAs在AF发展和进展中的作用.
在AF病理生理学中阐明ceRNA机制.
讨论针对AF的ncRNA途径的诊断,预后和治疗潜力.

主要方法:

关于ncRNAs和AF的研究的文献综述.
对涉及循环RNA (circRNAs),长非编码RNA (lncRNAs),微RNA (miRNAs) 和信使RNA (mRNAs) 的ceRNA网络的分析.
综合目前对AF中ncRNA介导基因调节的理解.

主要成果:

ncRNAs,特别是通过ceRNA机制,显著影响AF发展.
环RNA/lncRNA-miRNA-mRNA轴的失调与AF有关.
ncRNAs作为AF的生物标志物和治疗点表现有前途.

结论:

ncRNAs通过ceRNA网络在AF病原发生过程中发挥着关键作用.
针对ncRNA介导的ceRNA轴是一个有前途的策略来管理AF.
对ncRNA功能的进一步研究可能会导致新的AF诊断和治疗方法.

关键词:

心房动是一种心房动.网络 ceRNA 网络环RNA 环RNA 是一个环RNA.在cnRNA中.这是一个小RNARNA.

更多相关视频

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...