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相关概念视频

Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

8.5K
Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
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相关实验视频

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The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
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来自ISSPP PIPAC数据库的第二份年度报告

Michael Bau Mortensen1, Francesco Casella2, Özgül Düzgün3

  • 1Upper GI and HPB Section, Department of Surgery, Odense Universitetshospital, Odense, Denmark.

Pleura and peritoneum
|December 25, 2023
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概括

压力内气溶化疗 (PIPAC) 显示了内转移 (PM) 的有希望的结果. 来自ISSPP PIPAC数据库的现实数据支持其使用,具有显著的组织学反应率和基于癌症类型的可变生存结果.

关键词:
这是ISSPPPP.皮帕克 (PIPAC) 是一个国际组织.我们的数据库数据库数据库数据库.腹内转移的发生.

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The ITS2 Database
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科学领域:

  • 在瘤学瘤学.
  • 手术瘤学手术瘤学
  • 胃肠病学 胃肠病学

背景情况:

  • 腹转移 (PM) 在癌症治疗中是一个重大挑战.
  • 系统化疗对PM的疗效有限.
  • 压力内气溶化疗 (PIPAC) 提供了一种有针对性的方法.

研究的目的:

  • 评估PIPAC针对PM患者的治疗的现实结果.
  • 为了分析国际脏和腹膜研究协会 (ISSPP) PIPAC数据库中的数据.

主要方法:

  • 分析了2020年6月至2023年2月期间12个中心809名PM患者的数据.
  • 进行了2,456次PIPAC手术,重点关注反应率,不良事件和存活率.

主要成果:

  • 观察到组织学反应的高率 (PRGS≤2在80%中),特别是第三次PIPAC.
  • 严重并发症 (等级≥3b: 22%) 和不良事件 (等级≥3: 8%) 的低率.
  • 平均整体存活时间因原发性瘤而异,从10.7个月 (胃癌) 到27.1个月 (间皮瘤).

结论:

  • 伊斯普普PIPAC数据库提供了强有力的现实世界证据,支持PIPAC治疗PM.
  • PIPAC在改善组织学反应方面表现出有效性,并为各种原发性瘤提供生存益处.