无症状或轻度Omicron感染的癌症患者的长期病毒分泌:一项回顾性研究
Qiao Yang1, Ying He2, Yi Zhou3
1Department of Ultrasound, The 941st Hospital of the PLA Joint Logistic Support Force, Xining, 810007, People's Republic of China.
Infection and drug resistance
|December 25, 2023
概括
经历了Omicron感染的癌症患者面临着更高的长期病毒分泌的风险. 活跃的癌症疾病显著增加了这种风险,表明需要有针对性的监测和护理.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 在免疫功能低下的人群中,Omicron变异感染带来了独特的挑战.
- 持续的病毒泄露是疾病传播和患者康复的担忧.
- 癌症患者是脆弱群体,在感染后需要特别注意.
研究的目的:
- 为了确定与Omicron感染后癌症患者长期病毒分泌相关的风险因素.
- 为了比较癌症和非癌症患者之间的病毒分泌时间.
- 为了研究活跃癌症与非活跃癌症对病毒分泌的影响.
主要方法:
- 对1442名感染Omicron的患者的非识别数据的回顾性分析.
- 倾向性得分匹配,以平衡癌症和非癌症组之间的基线特征.
- 后勤回归以确定长时间 (≥7天) 病毒泄漏的风险因素.
主要成果:
- 与非癌症患者相比,癌症患者在持续≥7天的病毒泄漏中表现出明显更高的几率比率 (1.84),而非癌症患者.
- 在没有并发症的癌症亚组,未接种疫苗的个体和无症状病例中观察到长期流产的风险更高.
- 患有活跃癌症的患者的流产时间中位数较长 (10天而不是6天),流产时间≥7天的风险增加 (OR 5.33).
结论:
- 癌症疾病是Omicron感染后长期病毒流放的独立风险因素.
- 活跃的癌症疾病特别与持续病毒流失的风险增加有关.
- 研究结果强调需要更密切地监测癌症患者的病毒分泌,特别是那些患有活跃疾病的人.
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