在纳米颗粒上加载的Phoenix dactylifera提取物的潜在抗毒素菌效率
Majed H Wakid1,2, Muslimah N Alsulami3, Mohamed Farid4
1Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Infection and drug resistance
|December 25, 2023
概括
纳米颗粒 (SeNPs) 与枣树提取物相结合,在治疗老鼠慢性Toxoplasma gondii感染方面表现有前途. 这种新的方法可能为毒素菌的传统疗法提供了替代方案.
科学领域:
- 寄生虫学的寄生虫学
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 毒素菌是一种寄生性疾病,由*Toxoplasma gondii*引起.
- 它影响人类和各种动物物种.
- 目前用于慢性感染的治疗方法存在局限性.
研究的目的:
- 为了评估纳米颗粒 (SeNPs) 和装载在SeNPs上的*Phoenix dactylifera* (Pd) 提取物.
- 在小鼠模型中评估它们对慢性T. gondii感染的有效性.
- 为了探索这是一种替代标准的螺旋治疗.
主要方法:
- 64只雌性小鼠被分为八组,包括对照组和用螺旋素,SeNPs,Pd提取物和Pd-SeNPs的治疗.
- 来自沙特阿拉伯的枣树果实被用于提取物制备.
- 进行了寄生虫学,组织病理学和生物化学分析.
主要成果:
- 与对照组相比,使用Pd提取物加载在SeNPs (GVII和GVIII) 上的处理显著降低了寄生虫负载.
- 组织病理学检查显示大脑皮层变化的改善.
- 在GVIII和GVII中观察到微质标记物Iba-1和炎症性细胞因子的减少表达.
结论:
- 装载在SeNPs上的SeNPs和*P. dactylifera*提取物显示出对T. gondii*感染的潜在有效药物.
- 这种组合疗法对治疗慢性毒素菌有前途.
- 进一步的研究可能会证明这是一种可行的替代治疗方法.
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