是Corynebacterium striatum是一个新兴的假肢关节感染病原体,应该如何治疗?
1MD, The Doub Laboratory of Translational Bacterial Research, University of Maryland School of Medicine, 725 west Lombard Street, Baltimore, MD 21201, Maryland, USA.
Germs
|December 25, 2023
概括
Corynebacterium striatum 假肢关节感染 (PJI) 已经显著增加. 达普托米辛暴露是一种危险因素,并且分离物表现出可诱导的耐药性,使其成为不可靠的治疗方法. 范科米辛和线索利德仍然是选择,达尔巴万辛显示出潜力.
科学领域:
- 传染性疾病 传染性疾病
- 整形外科手术 整形外科手术
- 临床微生物学 临床微生物学
背景情况:
- 假肢关节感染 (PJI) 在骨科手术中构成了重大挑战.
- Corynebacterium striatum是一种越来越多地被认可的PJI病原体.
- 了解趋势和抗菌素敏感性对于有效管理至关重要.
研究的目的:
- 评估Corynebacterium striatum PJI最近发生的情况.
- 为了确定与C.striatum PJI相关的风险因素.
- 为了确定C.striatum.目前的抗生素敏感性模式.
主要方法:
- 从2017年1月到2022年7月的PJI案件的回顾性审查.
- 两个时间段之间的C.striatum PJI发病率的比较.
- 对保存的C.striatum分离物的抗菌敏感性测试.
主要成果:
- 观察到C.striatum PJI比例的统计学上显著增加 (1.98%至7.84%).
- 慢性伤口和先前的达普托米辛暴露是相关的危险因素.
- 隔离体对万科米辛,线索利德和达尔巴万辛具有均的敏感性,但对西普罗夫洛克萨辛,四环素和多环素具有耐药性.
- 在85.7%的隔离物中发现了可诱导的高水平达普托米辛耐药性.
结论:
- 状细菌 (Corynebacterium striatum) 是PJI中一个新兴的病原体.
- 临床医生必须意识到可诱导的达普素耐药性,限制其使用.
- 范科米辛和线索利德是可靠的选择;达尔巴万辛值得进一步研究.
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