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Updated: Jul 7, 2025

Detection of Protein Ubiquitination
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NaV1.7 的 C 终端被 NEDD4L 泛化

Katharine M Wright1, Hanjie Jiang2,3,4, Wendy Xia1

  • 1Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.

ACS bio & med chem Au
|December 25, 2023
PubMed
概括

E3结合酶NEDD4L针对NaV1.7通道进行无处不在,这是调节疼痛信号的关键步骤. 这项研究确定了NaV1.7上NEDD4L无处不在的特定部位,揭示了控制疼痛的新机制.

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