了解休时间的久坐行为对牙周炎的影响:一项两步,多变量门德尔随机化研究
Zhonghua Zhang1,2, Ming Ding1,2, Hui Ding3
1School of Stomatology, Zunyi Medical University, Zunyi, China.
Heliyon
|December 25, 2023
概括
休屏幕时间 (LST) 显著增加牙周炎的风险,吸烟部分调解了这一效应. 减少久坐的行为可能会降低牙疾病的风险.
科学领域:
- 口腔卫生流行病学 口腔卫生流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 休时间的久坐行为 (LSB) 与牙周炎风险之间的因果关系尚未得到充分证实.
- 这种关系中的潜在调解因素需要进一步调查.
研究的目的:
- 调查休时间久坐行为 (LSB) 对牙周炎风险的因果关系.
- 量化吸烟在LSB-牙周炎关联中的调解作用.
主要方法:
- 在大规模遗传关联研究中利用孟德尔的随机化 (MR) 分析.
- 采用了单变量,双步和多变量MR方法.
- 分析了来自欧洲血统参与者的数据.
主要成果:
- 休屏幕时间 (LST) 的1-SD增加与牙周炎风险增加23%有关 (OR=1.23).
- 吸烟部分介导了LST对牙周炎的影响,占因果效应的20.7%.
- 针对吸烟的多变量MR调整显示,LST和牙周炎之间存在较小但显著的关联 (OR=1.19).
结论:
- 提供了LST和牙周炎之间因果关系的证据.
- 强调吸烟作为一个重要的调解者,建议戒烟作为一种减少久坐不动个人牙周炎风险的策略.
- 支持减少休时间的久坐行为,以获得整体健康益处的建议.
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