癌症干细胞的免疫调节特征中的替代性免疫检查点
Keywan Mortezaee1, Jamal Majidpoor2
1Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Heliyon
|December 25, 2023
概括
瘤细胞通过替代免疫检查点 (AIC) 绕过免疫检查点抑制剂 (ICI) 治疗. 针对AICs,特别是那些影响癌症干细胞 (CSCs) 的AICs,提供了新的免疫疗法策略.
科学领域:
- 癌症免疫疗法癌症免疫疗法
- 瘤微环境 瘤微环境
- 癌症干细胞 癌症干细胞
背景情况:
- 针对PD-1,PD-L1和CTLA-4的免疫检查点抑制剂 (ICI) 疗法,由于瘤介导的耐药性而面临挑战.
- 替代性免疫检查点 (AICs) 在不响应的患者中是上调调的,包括B7家族成员和像IDO1.1这样的酶.
- AICs参与调节癌症干细胞和癌症干细胞 (CSCs) 的扩张,促进ICI耐药性.
研究的目的:
- 研究替代免疫检查点 (AIC) 与癌症的干性和分化概况之间的相互关系.
- 突出针对影响癌症干细胞 (CSC) 和免疫细胞的AIC的潜力,以改善免疫疗法.
主要方法:
- 关于替代免疫检查点 (AICs),癌症干细胞 (CSCs) 和它们在癌症免疫治疗中的作用的现有文献的综述.
- 分析AICs影响CSC特性和免疫逃避的机制.
- 探索涉及AIC和CSC的新型治疗策略.
主要成果:
- 替代性免疫检查点 (AICs) 在调节癌症干的过程中发挥着重要作用,并有助于抵抗标准ICI疗法.
- 抗癌细胞影响瘤免疫微环境 (TIME),并与癌症干细胞 (CSC) 种群有关.
- 针对特定的AIC基于它们对CSC和免疫细胞的影响,为癌症治疗提供了一个有希望的途径.
结论:
- 了解AIC和CSC之间的相互作用对于克服ICI阻力至关重要.
- 治疗策略应该考虑向调节CSC行为和免疫反应的AIC.
- 细胞外囊泡 (EV) 的ex vivo工程与CSC向的抗检点抗体代表了潜在的未来治疗方法.
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