在人类中,重复的疼痛经历调节了血液动力学的前进控制和通过氧化/氧气吸入的修饰
Hironori Miyazaki1, Yoshifumi Nishio1, Kohta Miyahara1
1Department of Special Care Dentistry, Hiroshima University, Hiroshima, Japan.
Heliyon
|December 25, 2023
概括
重复的疼痛导致预期的心率增加. 吸入氧化 (N2O) 可能通过降低血管硬性来减少这种效应,但只有当心率反应不存在时.
科学领域:
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
背景情况:
- 重复的压力可以触发中央指挥 (CC) 介导的心血管反应.
- 重复疼痛对预期性心血管反应的影响以及氧化/氧气 (N2O) 吸入的影响仍然不清楚.
研究的目的:
- 调查重复的冷压器测试 (CPT) 是否改变预期的心血管反应.
- 为了确定N2O是否减弱了这些改变的预期性心血管反应.
主要方法:
- 在休息,倒计时 (CD),CPT和恢复期间测量节拍血压,心率和动脉硬度.
- 在15名年轻成年人中,使用和不使用N2O吸入的重复性CPT.
主要成果:
- 在倒计时期间,重复的CPT诱导了feedforward心率的增加.
- 在最初的CPT期间,N2O吸入降低了缩血压和心率.
- 在倒计时期间,N2O减弱了预期性静脉血压反应,但只有当前心率增加缺席时.
结论:
- 重复的疼痛经历会导致心率的提升.
- 40%的N2O降低了血管硬度,当心率成分不存在时,可能会减轻预期压力反应.
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