估计印度人口的维生素D值:深入研究实际的疾病负担
Neha Gupta1, Anupam Agarwal2, Radhika Jindal3
1Classified Specialist (Pathology), Air Force Hospital, Hasimara, West Bengal, India.
维生素D缺乏在印度很普遍. 这项研究在健康的印度人中为血清25基胆酸 (25HCC) 设定了新的较低的参考范围,这对于准确的诊断和骨健康管理至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 由于种族和皮肤颜色等因素,目前的维生素D指南可能不适用于印度人口.
- 根据现有标准,很大一部分健康的印度人口表现出维生素D缺乏.
研究的目的:
- 在健康的印度人中确定血清25基胆酸 (25HCC) 水平的特定人群值.
- 建立25HCC的参考范围,与此人口群体的最佳骨健康和矿物质稳定相相关.
主要方法:
- 包括20-50岁的健康成年人,严格排除对影响维生素D代谢的疾病的排除标准.
- 对血清生物化学标记物的分析,包括,酸盐,性酸酶,25HCC,1,25dihydroxycholecalciferol和副甲状腺激素 (PTH).
- 利用本地估计的光滑散射图 (LOESS) 曲线和斯皮尔曼相关性来确定25HCC的值.
主要成果:
- 几乎所有参与者 (97.8%) 的维生素D水平低于30 ng/ml.
- 在25HCC和PTH (rs = -0.437) 和性酸酶 (rs = -0.1475) 之间观察到弱反相关性.
- 在25HCC和血清酸盐之间发现了微弱的正相关性 (rs = 0.128).
结论:
- 该研究在健康的印度人中确定了25HCC的较低参考范围,正常的下限约为13.5 ng/ml.
- 在这个人群中,维生素D缺乏症在25个HCC水平13.5ng/ml时是有迹象的,而缺乏症在7ng/ml时是有迹象的.
- 这些发现需要对印度人口的维生素D评估指南进行修订.
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