在ADHD成年人中,结构连接体的异常布线具有ADHD
Tuija Tolonen1, Timo Roine2,3, Kimmo Alho1,4
1Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Network neuroscience (Cambridge, Mass.)
|December 25, 2023
概括
患有注意力缺陷/多动障碍 (ADHD) 的成年人显示大脑网络中的白质连接性普遍下降. 这种低连接性,特别是在左前线区域,与注意力任务绩效缺陷相关.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 大脑的连接性 大脑的连接性
背景情况:
- 关于成人注意力缺陷/多动症 (ADHD) 大规模大脑网络中白质变化的知识仍然有限.
- 之前的研究主要利用功能神经成像,不太关注结构连接.
研究的目的:
- 研究ADHD成年人和神经类型对照之间的全脑结构连接网络的差异.
- 探索结构连接性,ADHD症状严重程度和认知任务的表现之间的关联.
主要方法:
- 扩散权重磁共振成像 (dMRI) 数据从40名ADHD成人和36名对照人群中获得.
- 用受约束球形解卷 (CSD) 路谱来重建结构性大脑网络.
- 基于网络的统计 (NBS) 和图形理论分析被用来比较网络属性.
主要成果:
- 基于网络的统计数据显示,与对照组相比,ADHD组中广泛的单边网络中的连接性显著下降.
- 受影响的网络包括下皮层,皮质皮层,背部/腹部注意力,视觉和体运动系统.
- 左前线网络的低连接性与康纳斯连续性能测试2 (CPT-2) 的佣金错误增加有关.
- 图形理论分析没有发现群体之间的显著拓差异或与症状/表现的相关性.
结论:
- 成年ADHD的特点是异常的结构布线,表现为广泛的半球内低连接性.
- 这些结构变化通过功能神经成像研究观察到以前与ADHD相关的网络.
- 研究结果强调了白质途径在成年ADHD神经生物学中的作用.
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