制备,稳定和体外运输以大豆蛋白为基础的迪奥斯基宁纳米乳液
Li Guanghui1, Liu Qi2, Gao Anning3
1Food and Pharmacy College, Xuchang University, Xuchang, Henan 461000, China.
Food chemistry: X
|December 25, 2023
概括
大豆蛋白分离纳米乳液有效封装二氧化原蛋白 (DIO),提高其溶解性和生物可用性. 这些装有DIO的纳米乳液表现出增强的稳定性和细胞透性,突出了它们作为药物输送系统的潜力.
科学领域:
- 食品科学与技术 食品科学与技术
- 纳米技术纳米技术
- 生物材料是一种生物材料.
背景情况:
- 狄奥斯基 (DIO) 的水溶性和生物利用性有限.
- 纳米乳液 (NEs) 为封装疏水化合物提供了一个有前途的方法.
- 大豆蛋白分离物 (SPI) 是一种潜在的生物聚合物,可以稳定NE.
研究的目的:
- 为DIO封装制定SPI稳定的NE.
- 调查DIO度对NE特性的影响.
- 评估DIO装载NE的稳定性和细胞透性.
主要方法:
- 用不同的DIO度配制SPI稳定的NE.
- 描述NE的物理化学特性 (滴滴大小,PDI,稳定性).
- 在不同的环境条件下 (pH,盐,温度,冷-解) 评估NE的稳定性.
- 评估细胞透性和DIO的细胞毒性.
主要成果:
- DIO显著影响了NE的物理化学特性.
- 最佳NE (1.0 mg/mL DIO) 显示小滴子大小 (209 nm),低PDI (0.17) 和高稳定性 (95.8%).
- 在各种pH,NaCl,温度条件和冷解周期中,DIO-SPI NEs表现出良好的稳定性.
- 封装降低了DIO的细胞毒性,提高了运输效率 (3.164.87 × 10−6).
结论:
- 基于SPI的NE是DIO的有效载体.
- 封装增强了DIO的可溶性,生物可用性和传递效率.
- 这些发现支持使用SPI-NE来改善二氧化原蛋白的输送.
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