与冠状动脉在心血管疾病风险较低的人群中具有积极的关联
Benjamin C Trumble1, Jacob Negrey1, Stephanie V Koebele1
1Arizona State University, School of Human Evolution and Social Change, Center for Evolution and Medicine, Institute of Human Origins, Tempe, AZ, USA.
Evolution, medicine, and public health
|December 25, 2023
概括
与天马族人群的冠状动脉有关,这挑战了工业化国家以前的发现. 这表明肥胖可能会混低和心血管疾病之间的关系.
科学领域:
- 人类生物学 人类生物学
- 心血管健康的心血管健康
- 内分泌学 在内分泌学.
背景情况:
- 低男性丸激素与工业化人口中较高的心血管死亡率有关.
- 冠状动脉风险因素,如肥胖,影响丸激素水平和心血管结果.
- 这项研究调查了内源性在冠状动脉的作用,在一个自给自足的人群中.
研究的目的:
- 评估内源性和冠状动脉 (CAC) 之间的关联.
- 为了在一个活跃的生存人口中检查这种关系,这些人通常具有低丸激素和低心血管风险.
- 探索工业化人口中潜在的混因素.
主要方法:
- 在玻利维亚亚亚马逊地区,对719名西马尼 (Tsimane) 采摘者-园艺家 (40岁以上) 进行了横截面研究.
- 计算机断层扫描被用来评估冠状动脉.
- 统计模型 (零膨胀负二项式) 分析了和CAC之间的关联.
主要成果:
- 在全样本中发现和冠状动脉之间存在正相关性 (IRR=1.477,P=0.031).
- 也与临床相关的冠状动脉样硬化有积极的关联 (几率比[OR]=1.984,P=0.007).
- 具有较高CAC分数的个体具有显著更高的丸激素水平.
结论:
- 与天马人的冠状动脉有关,尽管他们的水平很低,心血管疾病负担也很低.
- 在工业化人口中,低丸激素和心血管疾病之间的观察到的关联可能会被肥胖等因素所混.
- 研究结果表明,丸激素,动脉样硬化和生活方式因素之间存在复杂的相互作用.
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