评估阿曼塔丁对创伤性脑损伤后易怒和侵略性的益处和风险
Flora M Hammond1,2,3, Ross D Zafonte4, Mark Sherer5
1Department of Physical Medicine & Rehabilitation, Indiana University School of Medicine, Indianapolis, Indiana, USA.
PM & R : the journal of injury, function, and rehabilitation
|December 25, 2023
概括
阿曼塔丁在创伤性脑损伤后对易怒和侵略性提供了适度的好处,伤害风险较低. 临床医生应考虑选择创伤性脑损伤患者使用这种药物.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 创伤性脑损伤 (TBI) 可以导致持续的易怒和攻击性.
- 对这些TBI后行为障碍的有效药理干预是有限的.
- 目前,阿曼塔丁正在研究其治疗这些症状的潜力.
研究的目的:
- 量化阿曼塔丁在TBI后治疗易怒和侵略时的益处与危害.
- 计算需要治疗的数量 (NNTB) 的好处和需要治疗的伤害数量 (NNTH).
主要方法:
- 分析了一项随机对照多站点试验的二次结果数据.
- 每天两次服用100毫克的阿曼塔丁.
- 临床医生全球印象-全球改善量表用于评估患者的治疗结果和不良事件.
主要成果:
- 每六名阿曼塔丁治疗患者中,就有一名患者出现改善 (NNTB = 6.4).
- 虽然有更多的安慰剂组患者病情恶化,但这在统计学上并不显著 (NNTH = -92.4).
- 在阿曼塔丁和安慰剂组之间没有观察到不良事件的显著差异.
结论:
- 临床评价表明,阿曼塔丁对TBI相关的易怒和侵略有适度的益处.
- 在适当选择的具有足够功能的患者中,阿曼塔丁具有低风险概况.
- 阿曼塔丁是经验丰富的临床医生管理TBI行为症状的可行治疗选择.
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