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基于金属氧化物薄膜电子的多重复合表面电极阵列,用于高分辨率的皮层映射

Horacio Londoño-Ramírez^1,2,3,4, Xiaohua Huang^3,5, Jordi Cools^2,3,4

¹Department of Neuroscience, Leuven Brain Institute, Katholieke Universiteit (KU) Leuven, Leuven, 3001, Belgium.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|December 25, 2023

概括

研究人员使用薄膜晶体管开发了一种活性微电皮质谱 (μECoG) 植入物. 这项创新使得高密度的大脑记录能够使用更少的线路,推进神经科学研究和脑机界面.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

电皮质谱 (ECoG) 对于在研究和临床环境中记录大脑活动至关重要.
现有的被动ECoG系统在空间分辨率,皮质覆盖和系统紧性方面受到限制,这是由于单个电极的布线.
电极数量和密度受到瓶,因为每个电极需要专门的布线.

研究的目的:

提出一个活跃的微电皮质谱 (μECoG) 植入物,克服传统ECoG阵列的布线限制.
展示一种具有高电极密度和广泛皮质覆盖的新型神经接口.
为了使大量电极同时记录,降低噪音.

主要方法:

开发一种灵活的电极阵列,其中包含金属氧化物薄膜晶体管 (TFT).
集成的阵列与一个增量-ΔΣ读出集成电路 (ROIC).
实施16: 1时间分割多重复合方案,通过共享线路解决多个电极.
在小鼠体内验证,记录自发活动和体感官唤起的潜能.

主要成果:

活跃的μECoG植入物成功地记录了来自多达256个电极的神经活动.
与现有的活跃μECoG阵列相比,该系统显示噪声水平较低.
在大约8x8mm2的皮质表面面积上,在小鼠中实现了有效的记录.
该技术克服了传统ECoG系统固有的布线瓶.

结论:

拟议的活性μECoG神经接口比传统的ECoG技术提供了显著的进步.
这项技术对增强的大脑皮层绘制有希望.
它作为一种促进技术,用于开发复杂的未来大脑机器接口.

关键词:

一个-IGZOZO 的.电皮质谱 (电皮质谱) 是一种电皮质谱.电极阵列的电极阵列.灵活的电子产品灵活的电子产品薄膜晶体管的使用方法时间划分多重复合.在 μECoGs 中.

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