升高的XI因子与复发性脑静脉鼻血栓形成的风险增加有关:一个队列研究
Elżbieta Paszek1,2, Maciej Polak3, Anetta Undas4,5
1Clinical Department of Interventional Cardiology, John Paul II Hospital, Krakow, 31-202, Poland.
Journal of thrombosis and thrombolysis
|December 25, 2023
概括
高水平的XI因子 (FXI) 与脑静脉鼻血栓 (CVST) 和其复发的风险更高有关. 这一发现表明,FXI可能是CVST的新风险因素,可能引导新的治疗方法.
科学领域:
- 血液学 血液学 血液学
- 神经学 神经学
- 血栓形成研究研究
背景情况:
- 大脑静脉鼻血栓塞 (CVST) 在15%的病例中仍然是异常病.
- 升高的第八因子 (FVIII) 和第十一因子 (FXI) 是已知的血栓塞栓症风险因素,但它们在CVST中的特定作用尚未研究.
- 了解CVST的诱导因素对于预防初始和复发事件至关重要.
研究的目的:
- 调查假设,高血FVIII和FXI水平使个体易受首次和反复复发的CVST.
- 探索FVIII/FXI水平与CVST幸存者的纤维素凝块特性之间的关联.
- 确定CVST的潜在新型风险因素.
主要方法:
- 一项涉及50名CVST幸存者 (年龄<60岁) 和50名对照者的病例控制研究.
- 在停止使用抗凝血剂后测量血FVIII和FXI水平.
- 纤维素凝块性质的分析 (溶解时间,透性,D-二次数最大,D-二次数速率).
- 对CVST复发的随访时间平均为58.5个月.
主要成果:
- 与对照组相比,CVST幸存者的血FVIII水平显著更高 (22.7%更高,p=0.02).
- 增加的FXI水平 (>120%) 在CVST患者中更常见 (24%对8%,p=0.03) 并与复发CVST风险增加四倍相关 (p=0.01).
- 患有FVIII>150%的患者表现出较差的再通道化率 (15.4%与75.7%,p<0.001).
结论:
- 高血FXI水平,特别是超过120%,代表了初始和复发性CVST的潜在新风险因素.
- 这些发现表明,FXI可能在CVST的发病过程中发挥重要作用.
- 新兴的抗FXI疗法可能是CVST患者有前途的治疗途径.
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