通过妊娠期的阿司匹林的药理动力学和药理动力学
Rupsa C Boelig1, Gagan Kaushal2, Ankit Rochani3
1Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA; Department of Pharmacology, Physiology, and Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.
建议使用低剂量阿司匹林 (81毫克) 预防孕前. 这项研究发现,肥胖和并发症等个人因素会影响阿司匹林.
科学领域:
- 药理学和治疗学 药理学和治疗学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 临床药房 临床药房
背景情况:
- 低剂量阿司匹林被推用于妊娠前的预防,但最佳剂量仍然不清楚.
- 怀孕引起的生理变化可能会影响阿司匹林的药理动力学 (PK) 和药理动力学 (PD).
- 有限的数据存在在怀孕期间阿司匹林PK/PD关系,影响临床疗效.
研究的目的:
- 描述阿司匹林在整个怀孕期间 (第一和第三季度) 的PK和PD.
- 为了确定影响阿司匹林PK的个体共变量.
- 为了确定阿司匹林PK和PD之间的关系.
主要方法:
- 对每天服用81毫克阿司匹林的高危患者进行前性研究.
- 三次访问:第一季度 (基线PK),启动后2-4周,第三季度PK.
- 评估:体重,体重指数,血小板功能,尿液和血清血红素B2和血盐酸水平.
主要成果:
- 三季度之间PK参数的平均值没有显著变化,但在第三季度的峰值度较低的趋势.
- 肥胖和更高的BMI与较低的酸峰值水平和曲线下的面积有关.
- 阿司匹林有效地抑制了血栓和抑制了血小板功能,更强的抑制与更高的酸水平相关.
结论:
- 证明了个体因素,阿司匹林水平,血栓素抑制和血小板抑制之间的联系.
- 研究结果表明,在怀孕期间改变阿司匹林剂量可能会优化治疗反应.
- 结果可以为个性化阿司匹林剂量策略的计算建模提供信息.
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