一个历史性的,以证据为基础的,和叙事审查常用的食补充剂在降脂降脂
Jelani K Grant1, Michael Dangl2, Chiadi E Ndumele1
1Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Journal of lipid research
|December 25, 2023
概括
对于胆固醇健康的食补充剂很受欢迎,但缺乏严格的FDA监督. 它们的使用应该补充,而不是取代,已被证明的医疗疗法,以减少心血管疾病的风险.
科学领域:
- 营养科学 营养科学
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 食补充剂越来越受欢迎,超过50%的美国人口使用它们.
- 许多患者认为补充剂在降脂方面与传统疗法同样有效或更有效.
- 红酵母大米,omega-3s,大和黄等补充剂被广泛推销为"胆固醇健康".
研究的目的:
- 提供用于脂蛋白和降脂的食补充剂的历史和基于证据的审查.
- 与基于证据的疗法相比,解决患者对补充剂疗效的信念.
- 为管理患者对补充剂使用的期望提供一个框架.
主要方法:
- 关于食补充剂的历史和当前文献的叙事综述.
- 补充剂营销声明与科学证据对降脂的分析.
- 检查补充剂和药品之间的监管差异.
主要成果:
- 补充剂不受食品和药物管理局 (FDA) 与制药药物相同的严格制造,有效性或安全性审查.
- 在补充剂产品中,成分含量和含量可以显著不同.
- 支持许多降脂补充剂的有效性和安全性的证据往往有限或不一致.
结论:
- 虽然食补充剂具有历史意义,并吸引了对心血管风险的整体方法,但必须仔细考虑它们的使用.
- 应管理患者对补充剂有效性的期望,强调它们不应取代既有,基于证据的疗法.
- 需要进一步的研究和更明确的监管准则,以确保营销用于脂质管理的补充剂的安全性和有效性.
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