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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Ribosome Profiling02:24

Ribosome Profiling

3.5K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.5K

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相关实验视频

Updated: Jul 7, 2025

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

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在神经发育中研究 lncRNA 转录函数的技术.

Tara Srinivas1, Edilene Siqueira1, Sonia Guil2,3

  • 1Josep Carreras Leukaemia Research Institute (IJC), 08916, Badalona, Barcelona, Catalonia, Spain.

Molecular psychiatry
|December 25, 2023
PubMed
概括
此摘要是机器生成的。

由于它们的复杂性,在中枢神经系统 (CNS) 中研究长非编码RNA (lncRNA) 具有挑战性. 本综述详细介绍了研究中枢神经系统中ncRNA功能的方法,有助于神经发育和病理生理学研究.

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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相关实验视频

Last Updated: Jul 7, 2025

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
07:24

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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科学领域:

  • 基因组学就是基因组学.
  • 神经科学是一个神经科学.
  • 分子生物学分子生物学

背景情况:

  • 长非编码RNAs (lncRNAs) 是从哺乳动物基因组的很大一部分转录的.
  • 由于诸如基因组重叠和细胞类型特定表达等挑战,许多lncRNA具有未表达的功能.
  • 在哺乳动物的中枢神经系统 (CNS) 中,lncRNAs丰富多样.

研究的目的:

  • 审查目前用于研究中枢神经系统中 lncRNA 功能的方法.
  • 讨论这些方法的优点和局限性.
  • 为在中枢神经系统研究中测定 lncRNA 提供建议.

主要方法:

  • 审查现有的关于 lncRNA 调查技术的文献.
  • 分析适用于中枢神经系统模型的方法,包括体内研究.
  • 讨论研究大脑中的lncRNAs所面临的具体挑战.

主要成果:

  • 关于在中枢神经系统中进行 lncRNA 研究的各种方法的全面概述.
  • 评估不同的方法如何有助于理解神经发育和病理生理学.
  • 识别现场持续存在的挑战.

结论:

  • 有效地研究中枢神经系统中的lncRNAs,需要仔细选择合适的方法.
  • 需要进一步开发技术来克服目前的局限性.
  • 标准化的方法可以促进对神经系统过程中 lncRNA 作用的理解.