动脉硬度与血压变化之间的时间关系以及对心血管疾病的联合影响
Xue Tian1,2,3,4, Shuohua Chen5, Qin Xu1,2
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
概括
通过腕脉冲波速度 (baPWV) 测量的动脉刚性,似乎在静脉血压变化 (SBPV) 的增加之前发生. 高水平的baPWV和SBPV显著增加心血管疾病 (CVD) 的风险.
科学领域:
- 心血管科学 心血管科学
- 高血压研究 高血压研究
- 血管生物学 血管生物学
背景情况:
- 通过腕脉冲波速度 (baPWV) 评估的动脉硬与血压 (BP) 有关.
- baPWV与血压变化 (BPV),特别是缩血压变化 (SBPV) 之间的特定时间关系尚不清楚.
- 了解这种关系对于预测心血管疾病 (CVD) 发展至关重要.
研究的目的:
- 调查baPWV和SBPV之间的时间关系.
- 评估baPWV和SBPV对心血管疾病发病率的联合影响.
- 为了探索不同高血压状态之间的这种关系.
主要方法:
- 从2006年至2018年,对6632名参与者进行了长度研究,重复测量baPWV和BP测量.
- 使用顺序访问数据计算基线和后续SBPV.
- 应用交叉滞后分析来确定baPWV和SBPV之间的时间关联.
- 后勤回归分析,以评估baPWV和SBPV对心血管疾病的联合预测值.
主要成果:
- 在基线baPWV预测后续SBPV (β1=0.040,P=0.0012),但不是相反 (β2=0.009,P=0.3830) 的情况下,观察到一个显著的单向关系.
- 这种关联在正常血压和各种高血压亚组中保持一致.
- 升高的基线baPWV和随访SBPV与显著更高的心血管疾病风险相关 (OR=5.82,95% CI:2.50-12.60).
结论:
- 动脉硬度 (baPWV) 似乎在增加SBPV的发展之前,并可能对其产生影响.
- 高动脉硬度和SBPV升高的组合是未来心血管事件的重要预测因素.
- 这些发现强调了在心血管疾病风险评估中监测动脉硬度和血压变化的重要性.
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