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婴儿期因食物引起的过敏反应与以后的睡眠和饮食障碍有关
Shay Nemet1, Daniel Elbirt1, Keren Mahlab-Guri1
1Allergy and Clinical Immunology Unit, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Rehovot, Jerusalem, Israel.
概括
儿童早期的食物诱导过敏症 (FIA) 显著增加了患心理障碍,特别是饮食和睡眠障碍的风险. 这些情况可能会持续到成年期,需要早期诊断和干预.
科学领域:
- 儿科过敏和免疫学
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 食物诱导的过敏反应 (FIA) 越来越多地与心理障碍 (PD) 相关.
- 早期的FIA可能会对随后的PD发展产生特定的影响.
- 这项研究调查了早期发作的FIA的长期心理影响.
研究的目的:
- 评估早期生活中食物诱导的过敏反应和心理障碍的发展之间的关联.
- 为了确定特定类型的心理障碍与FIA相关的儿科患者.
- 评估儿童早期FIA后的PD的长期风险.
主要方法:
- 基于人口的,追溯的,匹配的队列研究.
- 包括从2001年至2021年的儿科患者 (≤18岁).
- FIA患者的倾向性得分与没有过敏的对照进行匹配.
- 多变量回归模型和卡普兰-梅尔分析来检查关联.
主要成果:
- 在FIA和任何PD (p<.001),睡眠障碍 (p<.001) 和饮食障碍 (p=.050) 之间发现了关联.
- 在3岁之前患有FIA的患者,累计患有PD的风险增加,包括饮食和睡眠障碍.
- 幼儿的主要过敏原包括牛奶,蛋和花生.
结论:
- 生命早期的FIA (3岁之前) 是晚年出现饮食和睡眠障碍的危险因素.
- 这些疾病可以表现出来,并持续到成年.
- 需要增加临床注意力,以准确诊断患有FIA的儿童的心理障碍.
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