功能性MRI评估血液中氧气依赖 (BOLD) 在移植异常功能:一个前性研究
Hashim Mohamed Farg1, Tarek El-Diasty1, Bedeir Ali-El-Dein2
1Radiology Department, Urology and Nephrology Center, Mansoura University, Egypt.
Acta radiologica (Stockholm, Sweden : 1987)
|December 26, 2023
概括
血液氧气水平依赖的磁共振成像 (BOLD-MRI) 可以区分急性排斥 (AR) 和急性管状缩 (ATN) 在移植中. 这种非侵入性技术评估内组织氧化变化,以诊断早期移植后功能障碍.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 血液氧气水平依赖的磁共振成像 (BOLD-MRI) 是一种非侵入性的功能成像技术,用于评估合移植功能障碍.
- 早期诊断同移植功能障碍对于患者的治疗结果至关重要.
研究的目的:
- 使用3T扫描仪评估BOLD-MRI的诊断性能.
- 在移植后期区分合移植功能障碍的原因.
主要方法:
- 对112名移植受体进行前性研究 (53人为对照组,18人急性排斥,41人急性管状缩).
- 使用快速场回声序获取T2*加权图像.
- 测量皮质R2* (CR2*),骨髓R2* (MR2*) 和骨髓对皮质R2*比率 (MCR).
主要成果:
- 平均MR2*在急性排斥 (AR) 组明显低于正常和急性管状亡 (ATN) 组 (P <0.001).
- 与AR和正常组相比,ATN组的MCR更高.
- 无论是MR2* (AUC=0.837) 和MCR (AUC=0.727) 都准确地区分了ATN与AR (P <0.001).
结论:
- BOLD-MRI是一种有价值的非侵入性诊断技术,用于早期移植后的功能障碍.
- 它可以通过测量内组织氧化变化来区分AR和ATN.
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