两个牙骨视网膜异常阳性Cane Corso狗的牙异常:一个案例系列
Alexandra T Brown1, R Michael Peak1, Christopher W Smithson1
1The Pet Dentist of Tampa Bay, Wesley Chapel, FL, USA.
Journal of veterinary dentistry
|December 26, 2023
概括
卡内科尔索犬的牙骨视网膜异常 (DSRA) 是一种由MIA3/TANGO1基因突变引起的原异常. 这项研究详细介绍了受影响狗的牙异常,包括牙生殖不完美症.
科学领域:
- 兽医遗传学 兽医遗传学
- 狗类病理学 狗类病理学
- 口腔医学是指口腔医学.
背景情况:
- 牙骨视网膜异常 (DSRA) 是一种新发现的Cane Corso犬的原异常.
- 这种情况与MIA3/TANGO1基因的拼接缺陷有关,影响TANGO1蛋白质的产生.
- 以前的研究发现了人类和淘汰赛小鼠的类似缺陷.
研究的目的:
- 为了描述两只经遗传确认的DSRA受影响的Cane Corso狗的牙放射和组织病理异常.
- 为了将临床,放射学和组织学发现与之前报告的MIA3/TANGO1接头缺陷病例进行比较.
- 强调兽医专业人员对DSRA遗传基础,遗传和临床表现的认识的重要性.
主要方法:
- 两只Cane Corso狗的案例系列介绍,其中两只狗具有遗传确认的DSRA.
- 口腔内射线扫描用于评估牙结构和异常.
- 牙组织的组织病理学检查.
- 对包括牙,骨,视网膜和骨科异常在内的临床症状的审查.
主要成果:
- 牙科发现包括内在变色,牙缺陷,骨折牙,延迟牙沉积,内牙疾病和牙硬组织损失.
- 组织病理学证实了牙生殖不完美 (DGI) 在这两种情况下.
- 临床特征与先前报告的MIA3/TANGO1拼接缺陷一致,包括视力丧失,矮身和.
结论:
- 在Cane Corso犬中,DSRA呈现出显著的牙异常,特别是牙发育不完美,与MIA3/TANGO1基因突变有关.
- 自体逆向遗传被证实,有商业遗传测试可用.
- 兽医意识和基因查对于管理和预防DSRA至关重要,建议进行载体杀菌或从育种计划中删除.
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