一种来自Zanthoxylum rhetsa的茎皮的新型类类类和其生物活动
Thi Hong Van Nguyen1,2, Thi Tuyen Tran1, Huu Nghi Do1,2
1Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam.
Natural product research
|December 26, 2023
概括
一种新的类化合物和来自Zanthoxylum rhetsa的五种已知的化合物显示出潜在的抗癌和抗菌活性. 化合物4还表明抑制了血管酶二转化酶.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 桑托西 (Zanthoxylum rhetsa) 是一种生物活性类化合物的植物来源.
- 类化合物具有不同的药理性质.
- 之前对Zanthoxylum物种的植物化学研究已经确定了各种化合物.
研究的目的:
- 从Zanthoxylum rhetsa茎树皮中分离和表征化物.
- 评估分离化合物的生物活性,包括抗癌,抗微生物和酶抑制作用.
主要方法:
- 使用色谱技术分离类化合物.
- 通过1D,2DNMR光谱学和质谱学阐明结构.
- 生物活性查,包括细胞系抑制,抗微生物测定和酶抑制测定 (体外和内).
主要成果:
- 他们分离出了一种新的类类类类化合物,6-丁二基类 (1),以及五种已知的类化合物 (2-6).
- 化合物1,2,5和6抑制了MCF7和A549癌细胞系;化合物3抑制了A549细胞.
- 所有化合物 (1-6) 对至少两种微生物菌株表现出抗菌活性.
- 化合物4在体外和体内表现出血管新素II转化酶抑制活性.
结论:
- 该研究确定了具有显著生物活性的Zanthoxylum rhetsa的新型和已知的化物.
- 隔离的化合物显示出作为抗癌,抗微生物和抗高血压剂的潜力.
- 这项研究扩大了Zanthoxylum rhetsa和Zanthoxylum属的已知植物化学特征.
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