小儿发烧性尿路感染的短时间口服抗生素治疗:一项随机试验
Giovanni Montini1,2, Antimo Tessitore3, Karen Console3
1Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italy.
Pediatrics
|December 26, 2023
概括
5天的阿莫西西林 - 克拉夫兰酸疗程有效治疗儿童发烧性尿路感染 (fUTIs),显示与标准10天疗程的非劣势. 这种较短的治疗减少了复发率,并为儿科fUTI管理提供了潜在的更方便的选择.
科学领域:
- 儿童传染病 儿童传染病
- 抗生素管理的管理.
- 临床试验方法论 临床试验方法论
背景情况:
- 儿童发烧性尿路感染 (fUTIs) 通常用10天的口服抗生素治疗.
- 优化抗生素持续时间对于有效治疗和减少耐药性至关重要.
研究的目的:
- 为了评估5天的阿莫西西林 - 克拉夫兰酸疗程与10天的儿童治疗FUTIs疗程的非劣质性.
- 评估复发率,临床恢复和与更短的抗生素持续时间相关的不良事件.
主要方法:
- 一个多中心的,随机的,受控的试验,涉及3个月至5岁的儿童,患有无并发性FUTI.
- 参与者接受了阿莫西西林-克拉夫兰酸盐治疗,时间为5天或10天.
- 主要终点:fUTI在治疗后30天内复发.
主要成果:
- 5天组的复发率为2.8%,而10天组的复发率为14.3%.
- 30天内FUTI复发率在短组中为1.4%,在标准组中为5.7%.
- 五天的疗程表现出与10天的疗程相比的非劣质性.
结论:
- 口服阿莫西西林-克拉夫兰酸5天疗程与治疗儿童FUTIs的10天疗程相比,效果不差.
- 较短的抗生素持续时间可能是儿科fUTI管理的可行选择.
- 进一步的研究可以探索长期的结果和抵抗模式.
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