种族差异影响了妊娠性尿甲酸盐混合物和婴儿生殖器测量之间的联系
Meghana Varde1, Roger B Newman2, Abby G Wenzel2
1Department of Global and Community Health, George Mason University, Fairfax, VA, United States.
Frontiers in reproductive health
|December 26, 2023
概括
在甲酸盐暴露对胎儿生殖器发育的影响方面存在种族差异. 孕期甲酸盐暴露与黑人婴儿的阴茎距离减少有关,具体的甲酸盐根据种族不同地驱动这些关联.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 围产期流行病学 围产期流行病学
背景情况:
- 酸盐是具有抗雄激素特性的内分泌干扰化学物质 (EDC).
- 酸盐的暴露很普遍,在个人护理产品,药物和塑料中发现.
- 之前的研究表明,美国妇女在甲酸盐暴露方面存在种族差异,这可能会影响胎儿的发育.
研究的目的:
- 在一个种族多样化的群体中,研究孕期暴露于甲酸盐混合物和生殖器发育之间的关联.
- 为了确定种族是否改变了甲酸盐暴露和胎儿生殖器发育之间的关系.
主要方法:
- 在南卡罗来纳州查尔斯顿 (2011-2014) 的152名非西班牙裔黑人和158名非西班牙裔白人妇女的前性队列研究.
- 在怀孕中期的尿样中测量了八种甲酸单代谢物.
- 通过超声波和产后阴茎距离 (AGD) 评估妊娠中期阴茎尺寸.
- 利用贝叶斯核机器回归,调整共变量,分析甲酸盐混合物对男性和女性婴儿生殖器发育的影响.
主要成果:
- 在黑人母亲的婴儿中,观察到较高的酸盐水平和减少的阿波尼尔距离之间的更强的关联.
- 单 (2-乙烯基) 甲酸 (MEHP) 是黑人女性的关键甲酸,而单甲酸 (MBP) 和单乙烯甲酸 (MEP) 是白人女性的关键甲酸.
- 在黑人妇女的婴儿中,发现了酸盐和阴茎体积减少之间的非线性关联,由单异丁酸盐 (MiBP) 和MBP驱动.
- 在黑人妇女的婴儿中,更大的甲酸盐暴露与更短的阴囊距离相关,MEP和单甲酸盐 (MBzP) 是重要的贡献者.
结论:
- 结果表明,黑人和白人女性之间的妊娠期甲酸盐暴露和胎儿生殖器发育之间的关联存在差异.
- 特定的甲酸代谢物似乎对生殖器发育有不同的影响,这取决于母亲的种族.
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