在新诊断出癌症的儿童中,增长差异化因子15 (GDF15) 的升高
Daniel V Runco1,2,3, Linda A DiMeglio1,4, Charles P Vanderpool1,5
1Department of Pediatrics, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, United States.
Frontiers in oncology
|December 26, 2023
概括
新诊断出癌症的儿童中,生长差异化因子15 (GDF15) 高. 在这项试点研究中,这种炎症标志物与人类测量或生活质量没有相关性.
科学领域:
- 儿科瘤学 儿科瘤学
- 生物标志物 生物标志物
- 癌症 卡切西亚 癌症 卡切西亚
背景情况:
- 增长分化因子15 (GDF15) 是一种炎症标志物,与成人癌症缓解症有关,但它在儿童癌症中的作用基本上尚未被探索.
- 在癌症患者中,GDF15与恶心,吐和厌食症的增加有关,有助于营养不良和空腹症.
- 没有先前的研究研究了新诊断的癌症儿童的GDF15水平.
研究的目的:
- 为了比较新诊断的癌症儿童的GDF15水平与年龄和性别匹配的对照.
- 在儿童癌症患者中,将GDF15水平与人体测量 (身高,体重,MUAC) 相关联.
- 评估癌症儿童GDF15水平与生活质量 (QOL) 的关系.
主要方法:
- 一项试点研究招募了57名新确诊癌症的儿童 (2-21岁) 和27名年龄和性别匹配的对照.
- 在基线和3个月后随访时使用ELISA测量血清GDF15水平.
- 人类测量指标 (身高,体重,MUAC) 和QOL (PedsQLTM) 在基线和随访时进行了评估.
主要成果:
- 在癌症队列中,基线GDF15水平明显高于对照组 (中位数为614.6 pg/mL) (中位数为320.5 pg/mL;p<0.001).
- 在可评估参与者的基线和3个月随访期间,GDF15水平没有显著变化 (N=18;p=0.702).
- 在GDF15的变化和身高,体重或MUAC的变化之间没有发现显著的相关性;然而,在随访时,腹明显恶化 (p=0.017).
结论:
- 与对照组相比,癌症儿童的GDF15在诊断时升高.
- 在这个儿科队列中,GDF15水平与人体测量或QOL没有相关性.
- 这项试点研究为未来研究GDF15的自然史和治疗潜力在儿科癌症缓解症的基础.
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