基托桑涂层的阿齐思罗密/齐普罗夫洛克萨加载的聚烯酸纳米颗粒:一种特征和功效研究
Alaa Eldeen Yassin1,2, Abdulkareem M Albekairy1,3, Mustafa E Omer4
1College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Nanotechnology, science and applications
|December 26, 2023
概括
这项研究成功地将阿齐思罗米辛和西普罗夫洛辛联合封装在桑涂层的纳米颗粒中,显著增强了它们对克莱布西拉肺炎的抗菌活性.
科学领域:
- 制药纳米技术 制药纳米技术
- 药物输送系统 药物输送系统
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 抗微生物药物耐药性构成了全球健康的重大威胁.
- 用阿齐思罗密 (AZ) 和西普洛素 (CIP) 联合治疗是一种提高疗效和对抗耐药性的策略.
- 需要新的药物输送系统来优化抗生素组合的性能.
研究的目的:
- 在桑涂层的聚合物纳米颗粒中共同封装阿齐思罗米辛和西普罗夫洛克萨辛.
- 评估联合封装纳米颗粒的物理化学特性和体外释放.
- 评估联合药物配方对克莱布西拉肺炎的增强抗菌活性.
主要方法:
- 使用双重乳液方法对AZ/CIP进行联合封装,使其成为酸盐涂层的聚合物纳米粒子.
- 纳米颗粒的尺寸,多分散度指数,泽塔潜力和热特性 (DSC) 的表征.
- 在体外药物释放研究和通过微稀释测定对Klebsiella pneumoniae进行抗菌活性评估.
主要成果:
- 获得了具有高均性 (PDI < 0.2) 和正泽塔电位 (8-11 mV) 的球形纳米粒子 (184-190 nm).
- 差异扫描热量计证实了封装的阿齐思罗米和西普罗夫洛克萨的无形状态.
- 试验室释放显示持续4天的释放特征,最小抑制度 (MIC) 值降低了至少15倍的西普罗夫洛克萨和60倍的阿齐思罗米.
结论:
- 成功地将阿齐思罗米辛和西普罗夫洛克萨辛联合封装成涂有奇托桑的聚合物纳米粒子.
- 开发的纳米粒子表现出理想的特征,包括均大小和高泽塔潜力.
- 桑涂层的纳米颗粒显著增强了阿齐思罗米和西普罗夫洛克萨的抗菌疗效.
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