新型双氨基连接物和Pd (II) 和Pt (II) 之间的相互作用协调和生物活动
Laiane S Oliveira1, Letícia B Rosa2, Daniele D Affonso3
1Institute of Chemistry, University of Campinas, Cidade Universitária Zeferino Vaz - Barão Geraldo, Campinas, São Paulo, Brazil.
Chembiochem : a European journal of chemical biology
|December 26, 2023
概括
合成了新的 (Pt) 和 (Pd) 复合物,并对其生物活性进行了测试. Pt(II) 综合体显示出抗瘤潜力,而Pd(II) 综合体显示出对SARS-CoV-2的抗病毒疗效.
科学领域:
- 无机化学 无机化学
- 药用化学 医学化学
- 抗病毒研究 抗病毒研究
背景情况:
- (II) 和 (II) 复合物与N-捐赠体连接体被研究为潜在的抗癌剂,基于西斯的成功.
- 合成了一种新的双酸N-捐赠体配体,N-[[4-(phenylmethoxy) phenyl]methyl]-2-pyridinemethanamine. 这是一种新的双酸N捐赠体配体.
研究的目的:
- 探索新型Pt (II) 和Pd (II) 复合物的抗寄生虫,抗病毒和抗瘤活性.
- 为了表征合成的联结体及其金属复合物.
主要方法:
- 使用单晶X射线衍射,NMR和HR-ESI-MS等技术合成和描述Pt(II) 和Pd(II) 复合物.
- 在体外评估抗瘤,抗莱什曼和抗病毒活性.
- 对抗多抗药性卵巢癌细胞系的药物耐药性概况的评估.
主要成果:
- 形成Pt(II) 和Pd(II) 的[MLCl2]复合体,并确认Pd(II) 复合体的正方形平面几何.
- Pt(II) 综合体对NCI/ADR-RES细胞具有显著的抗瘤活性,GI50为10.5μM.
- 联体和Pd(II) 复合体表现出显著的抗SARS-CoV-2活性,在50μM下将病毒复制量减少约65%.
结论:
- 新型Pt(II) 复合物显示出作为抗癌剂的前景,特别是在抗抗药性卵巢癌方面.
- 连接体及其Pd(II) 复合物具有针对SARS-CoV-2的显著抗病毒特性,需要进一步调查.
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