由大肠杆菌序列类型1193引起的早期发病感染在晚期早产和满期新生儿中
Emerging infectious diseases
|December 26, 2023
概括
新出现的Escherichia coli ST1193菌株是新生儿早期性败血症 (EOS) 的重要原因,具有高毒性和抗菌素耐药性. 需要进一步的研究来了解它们在新生儿中的病变发生.
科学领域:
- 微生物学 微生物学
- 新生儿科学 新生儿科学
- 基因组学就是基因组学.
背景情况:
- 早期发作的败血症 (EOS) 是一种严重的新生儿感染.
- 大肠杆菌是EOS的常见原因之一.
- 了解致病菌株的遗传特征对于有效的治疗和预防至关重要.
研究的目的:
- 使用全基因组测序,从新生儿EOS病例中鉴定大肠杆菌菌株的特征.
- 为了将这些菌株与母体阴道抽样中的大肠杆菌进行比较.
- 为了确定与新生儿感染相关的特定序列类型 (ST).
主要方法:
- 来自32例新生儿EOS病例 (2019-2021,法国) 的大肠杆菌分离物的全基因组测序.
- 与第三季度孕妇阴道拭片中的大肠杆菌菌株进行比较.
- 序列类型 (ST) 分析和毒性概况和抗菌素耐药性的评估.
主要成果:
- 在EOS和阴道大肠杆菌菌株之间,植物遗传群或毒性概况没有显著差异.
- 序列类型ST1193在19%的EOS病例中被发现,类似于高度毒性的ST95.
- 三种ST1193菌株引起脑膜炎,三种带有扩展谱β-乳糖酶;在阴道抽样中没有发现ST1193菌株.
结论:
- 新兴的大肠杆菌ST1193在新生儿中普遍存在,毒性强,并且在新生儿中具有抗微生物药物耐药性.
- 与ST1193相关的EOS的致病性需要进一步调查.
- 临床医生应在产前和新生儿护理中考虑大肠杆菌ST1193,确保适当的监测和治疗.
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