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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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在炎症性肠病中,细胞内膜网膜应激被上调,并为TLR2通路介导的炎症反应做出了贡献

Weijie Wu1, Yan Zhao2, Tian Hu1

  • 1Department of Digestive Diseases, Changsha Central Hospital Affiliated to University of South China, Changsha, Hunan, China.

Immunopharmacology and immunotoxicology
|December 26, 2023
PubMed
概括

细胞内膜网膜应激 (ERS) 促进了Toll-like受体2 (TLR2) 信号传递,增加了炎症性肠病 (IBD) 的炎症. 使用TUDCA抑制ERS会降低这种反应,这表明ERS和TLR2是IBD的治疗点.

关键词:
在 GRP78 中使用.在TLR2中,它是TLR2.这就是TNF-a.细胞内膜网膜的压力应激炎症性肠病是一种炎症性肠病.

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