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通过β-catenin激活,Wnt7a可以降低脑内皮屏障功能

Narek Manukjan1,2,3, Steven Chau1, Florian Caiment4

  • 1Department of Pharmacology and Toxicology, Maastricht University, 50 Universiteitssingel, P.O. Box 616, Maastricht, 6200 MD, The Netherlands.

Molecular neurobiology
|December 26, 2023
PubMed
概括

Wnt7a信号通过降低通过β-catenin的Claudin-5表达而降低内皮屏障完整性,影响血脑屏障的形成. HIF1α信号传递在血管生成中起作用,但不是紧密结节的调节.

关键词:
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