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甲状腺结节的癌症率和特征与宏化
Fatma Tuğçe Şah Ünal1, Asena Gökçay Canpolat2, Atilla Halil Elhan3
1Ankara University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey. f.tugcesah@gmail.com.
Endocrine
|December 26, 2023
概括
甲状腺结节与宏化显示出更高的恶性瘤率,但在多变量分析后,这种关联并不显著. 年轻的年龄,较高的TIRADS类别和特定的结节位置是甲状腺癌风险的关键指标.
科学领域:
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 甲状腺结核中的宏化是常见的超声波发现.
- 它们与恶性瘤的关联需要进一步调查,以完善诊断的准确性.
- 区分良性和恶性结节对于适当的患者管理至关重要.
研究的目的:
- 为了确定表现出宏化的甲状腺结节的恶性潜力.
- 评估其他超声波特征在诊断大化甲状腺结核中的恶性瘤中的作用.
- 评估甲状腺结节中恶性瘤的独立风险因素.
主要方法:
- 从2008年到2021年,对8250例甲状腺超声波 (美国) 病例进行了回顾性审查.
- 包括296名患有宏结节的患者和300名年龄/性别匹配的对照,没有化.
- 分析了细胞病理学数据 (贝塞斯达分类) 和美国特征.
主要成果:
- 在宏化组 (14.2%) 和对照组 (5.3%) 中,恶性瘤的发生率明显高.
- 单变量分析显示,宏化增加了恶性瘤的风险 (OR:2.935).
- 多变量分析确定年轻的年龄,较高的TIRADS类别和上/中区域局部化作为恶性瘤的显著预测因素,独立于宏化.
结论:
- 虽然宏结节的初始恶性瘤发病率较高,但在多变量分析后,这一发现并不能独立预测.
- 年龄较小,TIRADS得分较高和结节位置是评估恶性瘤风险的关键因素.
- 外围中断化与恶性瘤风险增加无关.
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