在主观认知衰退和轻度认知障碍中,被破坏的形态大脑网络组织
Yuxin Chen1,2, Lingyan Liang2, Yichen Wei2
1Medical College of Guangxi University, Guangxi University, Nanning, Guangxi, China.
Brain imaging and behavior
|December 26, 2023
概括
阿尔茨海默病早期阶段显示大脑网络发生变化. 主观认知衰退和轻度认知障碍揭示了被破坏的连接,可能是补偿机制.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 网络科学 网络科学
背景情况:
- 主观认知衰退 (SCD) 和轻度认知障碍 (MCI) 代表阿尔茨海默病 (AD) 连续的早期阶段.
- 了解这些阶段潜在的大脑变化对于早期检测和干预至关重要.
研究的目的:
- 用人类连接体方法研究SCD和MCI的灰色物质变化.
- 分析形态大脑网络 (MBN) 和它们与认知功能的关系.
主要方法:
- 获得54名SCD患者,95名MCI患者和65名健康对照 (HC) 的高分辨率T1加权MRI扫描.
- 基于灰色物质体积相似性的MBN的构造.
- 图形理论分析以比较网络属性并评估与蒙特利尔认知评估 (MoCA) 成绩的相关性.
主要成果:
- 在SCD与HC,MCI与SCD中,体运动和腹部注意网络之间的形态联系显著减少.
- 在MCI与SCD中,网络组织中断,由正常化最短路径长度增加和总效率降低 (Eg) 证明.
- 在SCD患者中,MoCA得分和Eg之间的负相关性.
结论:
- 形态网络异常存在于早期AD连续阶段 (SCD,MCI).
- 观察到的网络变化可能代表维持认知功能的补偿机制.
- 这些发现提供了对阿尔茨海默病进展机制的见解.
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