与代谢功能障碍相关的脂肪性肝病和心脏
Stan Driessen1, Sven M Francque2, Stefan D Anker3,4
1Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Hepatology (Baltimore, Md.)
|December 26, 2023
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与心脏病有关,与肥胖和糖尿病等常见风险因素有关. 对于患有MASLD的患者来说,全面的管理对于应对心血管风险至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率在全球范围内正在上升.
- MASLD经常与心脏代谢疾病同时发生,特别是动脉样硬化心血管疾病 (asCVD).
- MASLD和asCVD之间的关系需要对因果关系和查需求进行调查.
研究的目的:
- 审查MASLD和心脏病之间的相互关系.
- 解决共同发生,因果关系和管理策略的问题.
- 为MASLD和asCVD患者提供有关查和多学科护理的答案.
主要方法:
- 对MASLD患者动脉样硬化和心血管事件的流行病学研究的综述.
- 对门德尔随机化研究的分析,以探索因果关系.
- 检查共享的驱动因素和潜在的病理生理机制.
主要成果:
- MASLD患者的动脉样硬化增加,但心血管疾病死亡率并没有增加.
- 肥胖,胰岛素抵抗,T2DM,吸烟,高血压和睡眠呼吸暂停是共同的驱动因素.
- 通过超脂血症和心力衰竭,MASLD可能会导致动脉样硬化,在晚期有保存的喷射分数.
结论:
- MASLD和asCVD具有共同的风险因素和潜在的因果途径.
- 对MASLD患者来说,全面的心脏代谢风险管理是必不可少的.
- 建议采用多学科方法来管理MASLD及其心血管影响.
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