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通过功能化的多ADP-ribose聚合物产生双特异性抗体

Hyo Sun Kim1, Yong Zhang1,2,3,4

  • 1Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California.

Current protocols
|December 26, 2023
PubMed
概括

这项研究引入了一种创新的方法,用于使用化学修饰的聚-ADP-ribose聚合物制造双特异性抗体. 这种方法可以通过将抗体与特定的癌症标志物和免疫细胞联系起来,实现针对性的治疗.

关键词:
PARP1 的第一部分抗体是一种抗体.两种特异性抗体的抗体化学结合 化学结合 化学结合免疫疗法 免疫疗法聚ADP - 里糖的使用.后翻译修改后的修改

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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