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纳米颗粒与橄多醇的功能化 - 对毒性和抗氧化活性的影响

Emerik Galić^1,2, Kristina Radić², Nikolina Golub²

¹1Faculty of Agrobiotechnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek Croatia.

Acta pharmaceutica (Zagreb, Croatia)

|December 26, 2023

概括

纳米粒子 (SeNPs) 提供了更好的生物相容性. 用橄果汁提取物 (OPE) 功能化SeNPs增强了它们的抗氧化特性,创造了与无机相比毒性降低的新型营养药物.

科学领域:

纳米技术纳米技术
营养保健品营养保健品
生物化学生物化学

背景情况:

纳米粒子 (SeNPs) 是先进的 (Se) 配方,比无机Se具有更高的生物相容性和治疗指数.
橄果汁提取物 (OPE) 含有丰富的促进健康的多,为新型营养药物开发提供了机会.

研究的目的:

将SENPs与OPE功能化,创造创新的营养保健品.
评估功能化的SeNP的细胞毒性和抗氧化活性.

主要方法:

四种SeNP类型的合成和表征:PVP SeNP,PS SeNP,f PVP SeNP和f PS SeNP.
对HepG2和Caco2细胞的细胞毒性评估.
对抗激素和减少性质的评估.
对细胞内抗氧化机制的分析.

主要成果:

在HepG2和Caco2细胞上,SeNPs的毒性比塞莱尼特更低.
OPE的功能化显著提高了SeNPs的抗激素和减少能力.
对细胞内抗氧化机制的影响因细胞类型和SeNP特性而异.

结论:

功能化的SeNP代表具有增强抗氧化活性和降低毒性的有前途的营养药.
SeNP特征与细胞反应之间的相互作用凸显了它们生物效应的复杂性.

关键词:

抗氧化活性抗氧化活性细胞毒性细胞毒性聚醇是一种多醇.有活性氧物种的反应性氧物种.减少的谷氨二甲可以减少.纳米颗粒是一种纳米颗粒.

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