为提高生物可用性而制备阿斯塔桑/泽亚桑载荷的纳米结构脂质载体:特性,稳定性和透性研究
Kristina Radić1, Ana Isabel Barbosa2, Salette Reis2
11University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Food Chemistry 10000 Zagreb, Croatia.
Acta pharmaceutica (Zagreb, Croatia)
|December 26, 2023
概括
纳米结构脂质载体 (NLCs) 增强了阿斯塔桑 (ASTA) 和桑 (ZEA) 的稳定性和肠道吸收. 这些NLC为食品和制药应用提供了更好的交付.
科学领域:
- 营养药品和药物输送系统
- 纳米技术在食品和药品中的应用
背景情况:
- 阿斯塔桑丁 (ASTA) 和泽亚桑丁 (ZEA) 是具有健康益处的桑托菲尔类胡卜素.
- 生物可用性有限,溶解性差和不稳定性阻碍了ASTA和ZEA的利用.
- 降解和低吸收降低了ASTA和ZEA在食品和制药产品中的有效性.
研究的目的:
- 开发纳米结构脂质载体 (NLCs) 用于阿斯塔桑丁 (ASTA) 和泽亚桑丁 (ZEA).
- 为了提高ASTA和ZEA的稳定性,肠道透性和生物可用性.
- 评估NLC作为ASTA和ZEA在食品和制药行业的交付系统.
主要方法:
- 开发和描述ASTA和ZEA载荷的NLC.
- 物理化学表征:有效直径,多分散度指数 (PDI),泽塔电位和封装效率.
- 在储存和胃肠道条件下 (体外) 评估NLC稳定性.
主要成果:
- ASTA-NLCs和ZEA-NLCs表现出有利的物理化学特性 (例如,小颗粒大小,低PDI,负泽塔潜力).
- 在储存和模拟胃条件下,NLCs表现出良好的稳定性.
- 与自由化合物相比,在NLC中封装的ASTA和ZEA的肠道吸收显著增加,受粘液存在的影响.
结论:
- NLCs有效地保护ASTA和ZEA免受降解,并改善它们的肠道稳定性和吸收.
- 开发的NLC显示出作为ASTA和ZEA的先进交付系统的潜力.
- 这项研究支持在食品和制药行业应用NLC来增强胡卜素的输送.
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