与诺罗病毒GII.8[P8]相关的急性胃肠炎,泰国,2023年
Emerging infectious diseases
|December 26, 2023
概括
人类诺罗病毒GII.8[P8]在2023年6月在泰国引起了急性胃肠炎. 自2018年以来,这种基因型在泰国很少被检测到,在全基因组序列中没有发现重组的证据.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 人类诺罗病毒是全球急性胃肠炎爆发的主要原因.
- 诺罗病毒GII.8[P8]是一种新兴的基因型,已在各个地区检测到.
- 了解诺罗病毒流行病学对于有效控制疫情至关重要.
研究的目的:
- 在泰国普吉岛2023年急性胃肠炎疫情中涉及的诺罗病毒基因型的特征.
- 在泰国调查诺罗病毒GII.8[P8]的历史存在和遗传特征.
主要方法:
- 来自疫情的便样本被收集并分析诺罗病毒.
- 反转录聚合酶链反应 (RT-PCR) 用于放大诺罗病毒RNA.
- 在已识别的GII.8[P8]菌株上进行了全基因组测序.
- 进行了遗传学分析以确定遗传关系.
主要成果:
- 人类诺罗病毒GII.8[P8]被确定为2023年6月急性胃肠炎爆发的致病原体.
- 追溯分析显示,从2018年开始,在泰国不经常检测到GII.8[P8].
- 来自泰国的GII.8[P8]的十个全基因组序列没有显示出基因型重组的证据.
结论:
- 诺罗病毒GII.8[P8]至少自2018年以来一直在泰国传播.
- 基因型似乎稳定,在分析的序列中没有再组合的证据.
- 持续监测是必要的,以监测泰国诺罗病毒基因型的出现和演变.
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