在融合前和之后的流感血素中,保护人类抗体对保存表位的抗体进行保护
Joel Finney1,2, Annie Park Moseman2, Susan Kong1
1Laboratory of Molecular Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115.
概括
研究人员发现了人类抗体,可以对各种流感A和B病毒菌株进行保护. 这些抗体向血凝蛋白的保护区域,为更广泛的流感疫苗开发提供了潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 甲型和乙型流感病毒 (IAV和IBV) 引起人类重大疾病.
- 目前的流感疫苗针对不同地区,限制了广泛的保护.
- 已知很少有抗体可以中和IAV和IBV.
研究的目的:
- 调查自然存在的人类抗体的存在和保护能力,这些抗体针对保存的流感血质素 (HA) 表位.
- 探索这些抗体在开发通用流感疫苗方面的潜力.
主要方法:
- 从无关联的捐赠者中分离和表征5种人类单克隆抗体 (mAbs).
- 在IAV和IBV的融合后HA2构造上测试抗体与保存表位结合的抗体.
- 在小鼠模型中评估体内保护对致命的IAV和IBV的挑战.
主要成果:
- 确定了五种人类的mAbs,它们在HA2亚单元上结合了一种保存的表位,在融合后的构造中暴露.
- 这些抗体对小鼠的致命IAV和IBV感染表现出IgG亚型依赖的保护.
- 鉴定到的抗体没有表现出 in vitro 中和活性.
结论:
- 针对保存HA2表位的自然存在的人类抗体可以对各种流感A和B病毒提供显著的保护.
- 这些发现表明,诱导类似抗体的策略可能会导致更有效和更广泛的保护性流感疫苗.
关键词:
ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC is also known as ADCC ADCC ADCC is also known as ADCC流感疫苗和流感疫苗的使用记忆B细胞是一个B细胞.
相关概念视频
00:42Cross-reactivity
31.1K
Overview
31.1K
02:28Leaky Scanning
5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
01:10Antibody Structure
60.2K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.2K