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炎症性肠病患者无子女 - 来自前性多中心瑞士IBD队列研究的数据
Michael Christian Sulz1, Michael Doulberis2, Nicolas Fournier3
1Division of Gastroenterology and Hepatology, Cantonal Hospital Müsterlingen, 8596 Münsterlingen, Thurgau; Department of Gastroenterology and Hepatology, University Hospital Zurich (USZ), and Zurich University, Zurich, Switzerland. . michael.sulz@stgag.ch.
Journal of gastrointestinal and liver diseases : JGLD
|December 26, 2023
概括
患有克罗恩病 (CD) 的女性的无子率高于患有性结肠炎 (UC) 的女性或一般人群. 对于炎症性肠病 (IBD) 患者来说,生育能力的挑战很重要,需要临床关注.
科学领域:
- 胃肠病学 胃肠病学
- 生殖健康 生殖健康
- 流行病学 流行病学
背景情况:
- 无子女和不孕不育是炎症性肠病 (IBD) 患者常见的担忧.
- 关于IBD患者生殖的流行病学数据仍然有限.
- 瑞士炎症肠病队列研究 (SIBDCS) 为这项研究提供了大量的前性数据集.
研究的目的:
- 评估女性和男性IBD患者无子率.
- 为了确定IBD患者的累积生殖概率.
- 为了比较克罗恩病 (CD) 和性结肠炎 (UC) 患者之间的生殖结果.
主要方法:
- 分析了从SIBDCS中从3300多名IBD患者中前性收集的数据.
- 包括40岁以上的女性IBD患者,在30岁之前被诊断出IBD,以及那些积极试图怀孕的人.
- 包括没有孩子的男性积极试图怀孕.
主要成果:
- 32.1%的女性IBD患者年龄≥40岁,在30岁之前被诊断为IBD患者是没有孩子的.
- 在克罗恩病 (CD) (36.4%) 与性结肠炎 (UC) (21.8%) (p=0.026) 中,无子女率显著高.
- 试图怀孕的两分之一的女性在试图怀孕五年后没有怀孕或生育.
结论:
- 女性CD患者的不育率高于瑞士一般人口,而UC患者的不育率相似.
- 与UC患者相比,CD患者的平均儿童数量较低.
- 医疗保健专业人员应主动解决CD患者的生育问题,因为无子率较高.
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