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临床,内镜和组织病理学观察在胃肠粉样化症
Lea U Krauß1, Stephan Schmid2, Patricia Mester3
1Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany. . Lea.Krauss@ukr.de.
胃肠粉症经常导致出血,并表现出各种症状. 通过活检进行早期诊断对于管理这种具有挑战性的疾病至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 内部医学 内部医学
背景情况:
- 氨基粉症涉及错误折叠的蛋白质的细胞外沉积,可能会影响胃肠道 (GI).
- 胃肠道粉症增加了胃肠道出血的风险,特别是在粘膜病变时.
研究的目的:
- 为了确定GI表现的频率在amyloidosis患者.
- 为了临床表征患有肠道粉症的患者.
- 描述肠道粉症中的内镜和组织病理学发现.
主要方法:
- 对63名患有粉样化和胃肠道表现的患者进行了回顾性单中心研究.
- 从2003年7月到2023年6月收集的数据.
- 涉及对临床,内镜和组织病理学记录的审查.
主要成果:
- 23名患者 (36.5%) 患有肠道粉样化症 (平均年龄62岁). 粉样蛋白轻链 (AL) 是最常见的类型 (52.5%).
- 常见的胃肠道症状包括腹 (34.8%) 和腹痛 (30.4%). 结肠 (60.8%) 和胃 (39.1%) 最受影响.
- 内镜检查结果包括 (47.8%) 和炎症 (43.5%). 胃肠道出血发生在39.1%的患者中,五年死亡率为47.8%.
结论:
- 胃肠道粉症呈现出各种症状和内镜检查结果,使诊断复杂化.
- 胃肠道出血是一种严重而频繁的并发症.
- 活检确认对于最终的诊断和管理至关重要.
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