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Updated: Jul 7, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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在Myc诱导过程中,Csnk1a1平分不足和突变p53的协作作用可以促进白血病转化

Stijn N R Fuchs1,2, Ursula S A Stalmann1,2, Inge A M Snoeren1,2

  • 1Department of Developmental Biology, Erasmus Medical Center, Rotterdam, the Netherlands.

Blood advances
|December 26, 2023
PubMed
概括

在del ((5q) 骨髓质疏松症候群 (MDS) 中的遗传哈普洛缺陷,与Trp53中断相结合时,驱动白血病的发展. 一种CSNK1抑制剂通过降低Myc.的调节来有效治疗这些白血病.

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