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Updated: Jul 7, 2025

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue
11:08

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue

Published on: September 5, 2015

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泄漏通道和线粒体复合物I相互作用在小鼠脊髓的谷氨基内神经元中

Christian B Woods1, Beatrice Predoi1, Miranda Howe1

  • 1Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.

Anesthesiology
|December 26, 2023
PubMed
概括

通过NDi1酶恢复线粒体功能,可以防止像异富这样的挥发性麻醉剂在脊髓神经元中引起高极化电流. 这表明线粒体复合体I在麻醉作用中的关键作用.

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Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions10:45

Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions

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Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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The Role of Ion Channels in Neuronal Computation

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Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
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Resting Membrane Potential01:24

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The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
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