与社会焦虑症相关的肠道微生物群增加了社会恐惧
Nathaniel L Ritz1,2, Marta Brocka1, Mary I Butler1,3
1Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.
概括
肠道微生物组可能会因果关系地影响社会焦虑障碍 (SAD). 将SAD患者的肠道细菌移植到小鼠身上引发了社会恐惧,这表明微生物组是治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 社会焦虑障碍 (SAD) 是一种普遍存在的精神疾病,其生物学基础不清楚.
- 肠道微生物群影响大脑功能和行为,特别是社会行为.
- 免疫功能和催产素信号传递与社会反应有关.
研究的目的:
- 调查肠道微生物群组成在社会恐惧和SAD中的因果关系.
- 探索肠道微生物群,免疫功能和社交焦虑中的催产素信号之间的联系.
主要方法:
- 与对照组相比,16S rRNA测序确定了SAD患者的肠道微生物群组成差异.
- 从SAD患者的便微生物群移植到无菌小鼠中进行了.
- 用一系列测试来评估小鼠的焦虑和社会恐惧行为.
- 分析了中央和外周免疫标记物和催产素表达.
主要成果:
- 接受SAD微生物群的小鼠表现出高度的社会恐惧,这是SAD的一个模型,在一般焦虑或抑郁行为没有变化.
- 这种高度的社会恐惧与改变的中央和外周免疫功能有关.
- 观察到末的床核内的催产素表达的变化.
结论:
- 肠道微生物组在调节社会恐惧反应方面起着因果作用.
- 肠道微生物群和宿主神经免疫通路之间的跨王国轴影响社会焦虑.
- 肠道微生物组代表了社会焦虑障碍的潜在治疗点.
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